Issue 37, 2011
From the journal:

Chemical Communications

Cyclopenicillone, a unique cyclopentenone from the cultures of Penicillium decumbens†

Sheng Lin,‡a   Ting Shi,‡b   Ke-Yv Chen,a   Zhong-Xiao Zhang,a   Lei Shan,a   Yun-Heng Shena  and  Wei-Dong Zhang*a  

* Corresponding authors

a Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China
E-mail: wdzhangy@hotmail.com
Fax: +86-21-81871244
Tel: +86-21-81871244

b Department of Molecular Biology, Shanghai Jiao-Tong University School of Medicine, Shanghai, China

Abstract

Cyclopenicillone (1), possessing a unique 2,5-dimethylcyclopent-2-enone carbon skeleton, has been isolated from the cultures broth of the fungus Penicillium decumbens. The structure and absolute configuration of 1 were elucidated using a combination of NMR spectroscopy, CD data and computational approaches. Cyclopenicillone (1) demonstrated a dose-dependent (10–100 μM) inhibition against LPS-induced NO production in RAW264.7 macrophages.

Graphical abstract: Cyclopenicillone, a unique cyclopentenone from the cultures of Penicillium decumbens

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Article information

DOI
https://doi.org/10.1039/C1CC12079D
Article type
Communication
Submitted
12 Apr 2011
Accepted
26 Jul 2011
First published
11 Aug 2011

Chem. Commun., 2011,47, 10413-10415

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Cyclopenicillone, a unique cyclopentenone from the cultures of Penicillium decumbens

S. Lin, T. Shi, K. Chen, Z. Zhang, L. Shan, Y. Shen and W. Zhang, Chem. Commun., 2011, 47, 10413 DOI: 10.1039/C1CC12079D

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