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Issue 26, 2011
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A small molecule antagonist of ghrelin O-acyltransferase (GOAT)

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Abstract

Using our recently disclosed fluorescence-based assay to monitor acyltransferase activity, the first non-peptidic, small molecule antagonists of ghrelin O-acyltransferase (GOAT), a potential anti-obesity and anti-diabetes target, have been discovered. Each exhibits micromolar inhibition of the enzyme, and may be useful probes for future study of the ghrelin-GOAT system.

Graphical abstract: A small molecule antagonist of ghrelin O-acyltransferase (GOAT)

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Publication details

The article was received on 30 Mar 2011, accepted on 26 Apr 2011 and first published on 19 May 2011


Article type: Communication
DOI: 10.1039/C1CC11817J
Chem. Commun., 2011,47, 7512-7514

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    A small molecule antagonist of ghrelin O-acyltransferase (GOAT)

    A. L. Garner and K. D. Janda, Chem. Commun., 2011, 47, 7512
    DOI: 10.1039/C1CC11817J

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