Issue 30, 2011

Chemical activation of MEK1 – a redox trigger for evaluating the effects of phosphorylation

Abstract

An approach to generate mimics of phosphorylated serine proteins chemically through site-specific sulfonation of cysteine is presented. This chemical modification is reversible in the presence of reducing agent and therefore is analogous to the kinase/phosphatase system used in nature.

Graphical abstract: Chemical activation of MEK1 – a redox trigger for evaluating the effects of phosphorylation

Supplementary files

Article information

Article type
Communication
Submitted
27 Mar 2011
Accepted
20 Jun 2011
First published
30 Jun 2011

Chem. Commun., 2011,47, 8623-8625

Chemical activation of MEK1 – a redox trigger for evaluating the effects of phosphorylation

T. L. Lamoureaux and D. H. Lee, Chem. Commun., 2011, 47, 8623 DOI: 10.1039/C1CC11745A

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