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Issue 21, 2011
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Synthesis of thiophosphoramidates in water: Click chemistry for phosphates

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Abstract

An aqueous method for the preparation of N,S-dialkyl thiophosphoramidates is reported. Thiophosphorylation of alkylamines was performed using SPCl3 in aqueous reaction media, and the resulting thiophosphoramidate-S-anions were S-alkylated with soft electrophiles. Ranges of amines and electrophiles were explored.

Graphical abstract: Synthesis of thiophosphoramidates in water: Click chemistry for phosphates

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Article information


Submitted
18 Mar 2011
Accepted
08 Apr 2011
First published
26 Apr 2011

Chem. Commun., 2011,47, 6156-6158
Article type
Communication

Synthesis of thiophosphoramidates in water: Click chemistry for phosphates

M. Trmčić and D. R. W. Hodgson, Chem. Commun., 2011, 47, 6156
DOI: 10.1039/C1CC11586C

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