Manipulating DNA writhe through varying DNA sequences

Dawei Li; Zhaoqi Yang; Guanjia Zhao; Yi Long; Bei Lv; Cheng Li; Shuhui Hiew; Magdeline Tao Tao Ng; Juanjuan Guo; HongKee Tan; Hao Zhang; Tianhu Li

doi:10.1039/C1CC11543J

Manipulating DNA writhe through varying DNA sequences†

Dawei Li,*^a Zhaoqi Yang,^a Guanjia Zhao,^a Yi Long,^a Bei Lv,^a Cheng Li,^a Shuhui Hiew,^a Magdeline Tao Tao Ng,^a Juanjuan Guo,^a HongKee Tan,^a Hao Zhang^a and Tianhu Li*^a

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^a Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapor
E-mail: lida0006@e.ntu.edu.sg, thli@ntu.edu.sg
Fax: +65 6791-1961
Tel: +65 6513-7364

Abstract

It is demonstrated that the shapes and magnitudes of DNA writhe can be precisely manipulated solely through maneuvering the nucleotide sequence of DNA and without the assistance of topoisomerases.

Chemical Communications

Manipulating DNA writhe through varying DNA sequences†

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Manipulating DNA writhe through varying DNA sequences

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