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Issue 26, 2011
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Fluorous ligand capture (FLC): a chemoselective solution-phase strategy for isolating 99mTc-labelled compounds in high effective specific activity

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Abstract

A new approach for preparing 99mTc-labelled compounds in high effective specific activity was developed by utilizing a novel fluorous ligand capture (FLC) agent and a chemoselective filtration strategy. This paradigm eliminates the need to use HPLC to obtain technetium(I) based molecular imaging probes free from residual precursor.

Graphical abstract: Fluorous ligand capture (FLC): a chemoselective solution-phase strategy for isolating 99mTc-labelled compounds in high effective specific activity

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Publication details

The article was received on 23 Feb 2011, accepted on 04 May 2011 and first published on 31 May 2011


Article type: Communication
DOI: 10.1039/C1CC11079A
Chem. Commun., 2011,47, 7518-7520

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    Fluorous ligand capture (FLC): a chemoselective solution-phase strategy for isolating 99mTc-labelled compounds in high effective specific activity

    J. W. Hicks, L. E. Harrington and J. F. Valliant, Chem. Commun., 2011, 47, 7518
    DOI: 10.1039/C1CC11079A

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