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Issue 17, 2011
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The 2-thiouridine unit in the RNA strand is desulfured predominantly to 4-pyrimidinone nucleoside under in vitro oxidative stress conditions

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Abstract

The 2-thiouridine (S2U) unit in the RNA strand is predominantly desulfured with H2O2 to 4-pyrimidinone nucleoside (H2U). The resulting H2U-RNA exhibits significantly lower binding affinity to its complementary strand and in certain conditions undergoes strand scission. These results may explain the tRNA loss of biological function in oxidative stress conditions.

Graphical abstract: The 2-thiouridine unit in the RNA strand is desulfured predominantly to 4-pyrimidinone nucleoside under in vitro oxidative stress conditions

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Supplementary files

Article information


Submitted
18 Feb 2011
Accepted
10 Mar 2011
First published
24 Mar 2011

Chem. Commun., 2011,47, 4914-4916
Article type
Communication

The 2-thiouridine unit in the RNA strand is desulfured predominantly to 4-pyrimidinone nucleoside under in vitro oxidative stress conditions

E. Sochacka, K. Kraszewska, M. Sochacki, M. Sobczak, M. Janicka and B. Nawrot, Chem. Commun., 2011, 47, 4914
DOI: 10.1039/C1CC10973A

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