Issue 19, 2011
From the journal:

Chemical Communications

Synthesis and evaluation of a tri-tyrosine decorated dextran MR contrast agent for vulnerable plaque detection†

Anne Beilvert,*ab   Roger Vassy,ab   Emmanuelle Canet-Soulas,c   Olivier Rousseaux,d   Luc Picton,e   Didier Letourneurab  and  Frédéric Chaubetab  

* Corresponding authors

a Inserm, U698, Cardiovascular Bio-engineering, CHU X. Bichat, University Paris 7, Paris, France

b Institut Galilée, University Paris 13, Villetaneuse, France
E-mail: frederic.chaubet@univ-paris13.fr
Fax: +33 (0)1 4025 8602
Tel: +33 (0)1 4025 8600

c Université Lyon 1, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France

d Guerbet, Research Division, Aulnay-Sous-Bois, France

e University of Rouen, Lab. Polymers Biopolymers Surfaces—CNRS UMR 6270 & FR 3038 76821, Mont Saint Aignan, France

Abstract

This communication reports the synthesis, characterization and in vivo evaluation in mice of a new tri-tyrosine conjugated MR contrast agent, which may help to identify vulnerable plaques in atherosclerosis by targeting the lipid core.

Graphical abstract: Synthesis and evaluation of a tri-tyrosine decorated dextran MR contrast agent for vulnerable plaque detection

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Article information

DOI
https://doi.org/10.1039/C1CC10849B
Article type
Communication
Submitted
14 Feb 2011
Accepted
16 Mar 2011
First published
01 Apr 2011

Chem. Commun., 2011,47, 5506-5508

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Synthesis and evaluation of a tri-tyrosine decorated dextran MR contrast agent for vulnerable plaque detection

A. Beilvert, R. Vassy, E. Canet-Soulas, O. Rousseaux, L. Picton, D. Letourneur and F. Chaubet, Chem. Commun., 2011, 47, 5506 DOI: 10.1039/C1CC10849B

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