A new three-component reaction: green synthesis of novel isoindolo[2,1-a]quinazoline derivatives as potent inhibitors of TNF-α

K. Siva Kumar; P. Mahesh Kumar; K. Anil Kumar; M. Sreenivasulu; Ahamed A. Jafar; D. Rambabu; G. Rama Krishna; C. Malla Reddy; Ravikumar Kapavarapu; K. Shivakumar; K. Krishna Priya; Kishore V. L. Parsa; Manojit Pal

doi:10.1039/C1CC10715A

A new three-component reaction: green synthesis of novel isoindolo[2,1-a]quinazoline derivatives as potent inhibitors of TNF-α†

K. Siva Kumar,^ab P. Mahesh Kumar,^a K. Anil Kumar,^a M. Sreenivasulu,^a Ahamed A. Jafar,^b D. Rambabu,^c G. Rama Krishna,^d C. Malla Reddy,^d Ravikumar Kapavarapu,^c K. Shivakumar,^c K. Krishna Priya,^c Kishore V. L. Parsa^c and Manojit Pal*^c

Author affiliations

* Corresponding authors

^a Custom Pharmaceutical Services, Dr Reddy's Laboratories Limited, Bollaram Road Miyapur, Hyderabad, India

^b PG and Research Department of Chemistry, Jamal Mohamed College, Tiruchirappalli, Tamil Nadu, India

^c Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, India

^d Department of Chemical Sciences, Indian Institute of Science Education and Research, West Bengal, Kolkata, India

Abstract

Concurrent construction of five and six membered fused N-heretocyclic ring was achieved via a conceptually new three-component reaction affording 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-diones as novel inhibitors of TNF-α in vitro. This represents one of the few examples of direct TNF-α inhibition by small molecules.

Chemical Communications

A new three-component reaction: green synthesis of novel isoindolo[2,1-a]quinazoline derivatives as potent inhibitors of TNF-α†

Abstract

Supplementary files

Article information

Download Citation

Permissions

A new three-component reaction: green synthesis of novel isoindolo[2,1-a]quinazoline derivatives as potent inhibitors of TNF-α

Social activity

Search articles by author

Spotlight

Advertisements