Issue 18, 2011
From the journal:

Chemical Communications

Endosome-escapable magnetic poly(amino acid) nanoparticles for cancer diagnosis and therapy†

Hee-Man Yang,a   Hyun Jin Lee,a   Chan Woo Park,a   Se Rim Yoon,a   Sujin Lim,b   Bong Hyun Jungb  and  Jong-Duk Kim*a  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering (BK21 Graduate Program), Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea
E-mail: jdkim@kaist.ac.kr
Fax: +82-42-350-3910
Tel: +82-42-350-3961

b BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-701, Republic of Korea

Abstract

Endosome-escapable poly(amino acid) nanoparticles composed of iron oxide nanocrystals and anticancer drugs were prepared and demonstrated high T2 relaxivity coefficients and higher efficacy attributed to the endosomolytic ability of the conjugated histidine moiety.

Graphical abstract: Endosome-escapable magnetic poly(amino acid) nanoparticles for cancer diagnosis and therapy

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Article information

DOI
https://doi.org/10.1039/C1CC10371G
Article type
Communication
Submitted
19 Jan 2011
Accepted
17 Mar 2011
First published
30 Mar 2011

Chem. Commun., 2011,47, 5322-5324

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Endosome-escapable magnetic poly(amino acid) nanoparticles for cancer diagnosis and therapy

H. Yang, H. J. Lee, C. W. Park, S. R. Yoon, S. Lim, B. H. Jung and J. Kim, Chem. Commun., 2011, 47, 5322 DOI: 10.1039/C1CC10371G

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