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Issue 16, 2011
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Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes

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Abstract

A novel class of paramagnetic liposome-based systems acting as dual T1 and CEST 1H-MRI contrast agents is described. The vesicles contain a shift reagent in the aqueous core and a Gd-complex on the external surface conjugated through a biodegradable linker. As such, the probe can generate T1 contrast only, but after the cleavage and removal of the Gd-coating, the CEST contrast is switched on.

Graphical abstract: Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes

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Publication details

The article was received on 10 Jan 2011, accepted on 22 Feb 2011 and first published on 15 Mar 2011


Article type: Communication
DOI: 10.1039/C1CC10172B
Chem. Commun., 2011,47, 4667-4669

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    Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes

    E. Terreno, C. Boffa, V. Menchise, F. Fedeli, C. Carrera, D. D. Castelli, G. Digilio and S. Aime, Chem. Commun., 2011, 47, 4667
    DOI: 10.1039/C1CC10172B

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