Issue 15, 2011
From the journal:

Chemical Communications

A 4-[(3R,4R)-dihydroxypyrrolidino]pyrimidin-2-one nucleobase for a CG base pair in triplex DNA†

Yoshiyuki Hari,*a   Masaaki Akabane,a   Yuri Hatanaka,a   Motoi Nakaharaa  and  Satoshi Obika*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita 565-0871, Japan
E-mail: hari@phs.osaka-u.ac.jp, obika@phs.osaka-u.ac.jp
Fax: +81 6 6879 8201
Tel: +81 6 6879 8201+81 6 6879 8200

Abstract

In order to expand target sequences in triplex DNA formation, the development of a nucleobase that recognizes a CG base pair in dsDNA was attempted. A 4-[(3R,4R)-dihydroxypyrrolidino]pyrimidin-2-one nucleobase was found to recognize a CG base pair with high sequence-selectivity.

Graphical abstract: A 4-[(3R,4R)-dihydroxypyrrolidino]pyrimidin-2-one nucleobase for a CG base pair in triplex DNA

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Article information

DOI
https://doi.org/10.1039/C1CC10138B
Article type
Communication
Submitted
07 Jan 2011
Accepted
22 Feb 2011
First published
09 Mar 2011

Chem. Commun., 2011,47, 4424-4426

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A 4-[(3R,4R)-dihydroxypyrrolidino]pyrimidin-2-one nucleobase for a CG base pair in triplex DNA

Y. Hari, M. Akabane, Y. Hatanaka, M. Nakahara and S. Obika, Chem. Commun., 2011, 47, 4424 DOI: 10.1039/C1CC10138B

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