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Issue 16, 2011
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Evaluation of Aβ fibrillization inhibitory effect by a PEG–peptide conjugate based on an Aβ peptide fragment with intramolecular FRET

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Abstract

A PEG–peptide conjugate based on an amyloid β peptide fragment was synthesized. The formed amyloid protofibril-like aggregates induced intramolecular FRET. It proved to be useful as a bioprobe to evaluate the inhibitory effect of organic molecules toward amyloid fibrillization.

Graphical abstract: Evaluation of Aβ fibrillization inhibitory effect by a PEG–peptide conjugate based on an Aβ peptide fragment with intramolecular FRET

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Publication details

The article was received on 20 Dec 2010, accepted on 02 Mar 2011 and first published on 17 Mar 2011


Article type: Communication
DOI: 10.1039/C0CC05668E
Chem. Commun., 2011,47, 4709-4711

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    Evaluation of Aβ fibrillization inhibitory effect by a PEG–peptide conjugate based on an Aβ peptide fragment with intramolecular FRET

    T. Sakurai, T. Iwasaki, T. Okuno, Y. Kawata and N. Kise, Chem. Commun., 2011, 47, 4709
    DOI: 10.1039/C0CC05668E

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