Issue 11, 2011

Anaerobic conditions to reduce oxidation of proteins and to accelerate the copper-catalyzed “Click” reaction with a water-soluble bis(triazole) ligand

Abstract

Oxidation of protein (bovine albumin serum) by air still occurred under the copper-catalyzed azidealkyne cycloaddition (CuAAC) reaction conditions even in the presence of a Cu(I)-stabilizing tris(triazole) ligand. Anaerobic conditions not only avoided the oxidation of the protein, but also greatly accelerated the CuAAC reaction using a water-soluble bis(triazole) Cu(I) ligand.

Graphical abstract: Anaerobic conditions to reduce oxidation of proteins and to accelerate the copper-catalyzed “Click” reaction with a water-soluble bis(triazole) ligand

Supplementary files

Article information

Article type
Communication
Submitted
05 Dec 2010
Accepted
12 Jan 2011
First published
31 Jan 2011

Chem. Commun., 2011,47, 3186-3188

Anaerobic conditions to reduce oxidation of proteins and to accelerate the copper-catalyzed “Click” reaction with a water-soluble bis(triazole) ligand

A. Kumar, K. Li and C. Cai, Chem. Commun., 2011, 47, 3186 DOI: 10.1039/C0CC05376G

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