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Issue 11, 2011
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A facile direct anti-selective catalytic asymmetric Mannich reaction of aldehydes with preformed N-Boc and N-Cbz imines

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Abstract

Anti-selective Mannich reactions of N-Boc and N-Cbz protected imines with unmodified aldehydes proceeded smoothly under the catalysis of a secondary aminethiourea catalyst, which led to high yields (70%–95%) and excellent enantioselectivity (up to 96 ∶ 4 dr and >99% ee) under conventional organic synthetic operations.

Graphical abstract: A facile direct anti-selective catalytic asymmetric Mannich reaction of aldehydes with preformed N-Boc and N-Cbz imines

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Publication details

The article was received on 29 Nov 2010, accepted on 12 Jan 2011 and first published on 31 Jan 2011


Article type: Communication
DOI: 10.1039/C0CC05249C
Chem. Commun., 2011,47, 3260-3262

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    A facile direct anti-selective catalytic asymmetric Mannich reaction of aldehydes with preformed N-Boc and N-Cbz imines

    Y. Chuan, G. Chen, J. Gao, H. Zhang and Y. Peng, Chem. Commun., 2011, 47, 3260
    DOI: 10.1039/C0CC05249C

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