Issue 12, 2011
From the journal:

Chemical Communications

Human telomeric G-quadruplexes undergo dynamic conversion in a molecular crowding environment†

Liang Xu,a   Shuo Fenga  and  Xiang Zhou*ab  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, State Key Laboratory of Virology, Wuhan University, Hubei, Wuhan, P. R. China
E-mail: xzhou@whu.edu.cn
Fax: +86-27-68756663

b State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, P. R. China

Abstract

We provide a novel insight into dynamic conversion of the human telomeric G-quadruplexes and particularly a step-to-step transformation pathway of the long sequence containing two quadruplex units in K+ solution in a molecular crowding environment, implying a possible behavior of the human telomeric DNA under physiological conditions.

Graphical abstract: Human telomeric G-quadruplexes undergo dynamic conversion in a molecular crowding environment

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Article information

DOI
https://doi.org/10.1039/C0CC05242F
Article type
Communication
Submitted
29 Nov 2010
Accepted
25 Jan 2011
First published
10 Feb 2011

Chem. Commun., 2011,47, 3517-3519

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Human telomeric G-quadruplexes undergo dynamic conversion in a molecular crowding environment

L. Xu, S. Feng and X. Zhou, Chem. Commun., 2011, 47, 3517 DOI: 10.1039/C0CC05242F

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