Issue 9, 2011
From the journal:

Chemical Communications

In situ molecular detection of ischemic cells by enhanced protein direct electron transfer on a unique horseradish peroxidase–Au nanoparticles–polyaniline nanowires biofilm†

Chun Xian Guo,‡a   Xin Ting Zheng,‡a   Shu Rui Ng,a   Yicheng Lai,b   Yu Leic  and  Chang Ming Li*a  

* Corresponding authors

a Center for Advanced Bionanosystems and School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore
E-mail: Ecmli@ntu.edu.sg
Fax: +65 6791 1761
Tel: +65 6790 4485

b Data Storage Institute, A*STAR, Singapore 117608, Singapore

c Department of Chemical, Materials and Biomolecular Engineering, University of Connecticut, Storrs, USA

Abstract

To overcome shortcomings of the ex situ approaches, in situ detection using H2O2 molecules to diagnose ischemia through enhanced protein direct electron transfer on a unique horseradish peroxidase–Au nanoparticles–polyaniline nanowires biofilm is demonstrated and it is discovered that the extracellular H2O2 molecule released per ischemic cell is 2.7-times of that of a normal cell.

Graphical abstract: In situ molecular detection of ischemic cells by enhanced protein direct electron transfer on a unique horseradish peroxidase–Au nanoparticles–polyaniline nanowires biofilm

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Article information

DOI
https://doi.org/10.1039/C0CC04542J
Article type
Communication
Submitted
21 Oct 2010
Accepted
14 Dec 2010
First published
13 Jan 2011

Chem. Commun., 2011,47, 2652-2654

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In situ molecular detection of ischemic cells by enhanced protein direct electron transfer on a unique horseradish peroxidase–Au nanoparticles–polyaniline nanowires biofilm

C. X. Guo, X. T. Zheng, S. R. Ng, Y. Lai, Y. Lei and C. M. Li, Chem. Commun., 2011, 47, 2652 DOI: 10.1039/C0CC04542J

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