Issue 10, 2011

Highly regio- and stereoselective synthesis of alkenylboronic esters by copper-catalyzed boron additions to disubstituted alkynes

Abstract

The copper-catalyzed addition of bis(pinacolato)diboron to internal alkynes in the presence of methanol generates alkenylboron compounds with high levels of regio- and stereoselectivities. The catalytic efficiency is increased by using monodentate phosphine ligands, especially P(p-tolyl)3 and a range of internal alkynes was borylated in good yields.

Graphical abstract: Highly regio- and stereoselective synthesis of alkenylboronic esters by copper-catalyzed boron additions to disubstituted alkynes

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
19 Oct 2010
Accepted
24 Dec 2010
First published
24 Jan 2011

Chem. Commun., 2011,47, 2943-2945

Highly regio- and stereoselective synthesis of alkenylboronic esters by copper-catalyzed boron additions to disubstituted alkynes

H. R. Kim and J. Yun, Chem. Commun., 2011, 47, 2943 DOI: 10.1039/C0CC04496B

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