Issue 9, 2011
From the journal:

Chemical Communications

The tightly regulated copper window in yeast†

Seraphine V. Wegner,a   Fei Sun,a   Nick Hernandeza  and  Chuan He*a  

* Corresponding authors

a Department of Chemistry and Institute of Biophysical Dynamics, University of Chicago, 929 East 57th Street, Chicago, USA
E-mail: chuanhe@uchicago.edu
Fax: +1 773 702 0805
Tel: +1 773 702 5061

Abstract

The two opposing yeast copper regulators, Ace1 and Mac1, were converted into two fluorescent probes, Ace1-FRET and Mac1-FRET, which selectively and sensitively respond to Cu+. The Cu+-binding curves obtained for both regulators as well as for the copper storage proteins Cup1 and Crs5 show that free copper(I) is maintained in a narrow window inside yeast.

Graphical abstract: The tightly regulated copper window in yeast

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Article information

DOI
https://doi.org/10.1039/C0CC04292G
Article type
Communication
Submitted
08 Oct 2010
Accepted
07 Dec 2010
First published
21 Dec 2010

Chem. Commun., 2011,47, 2571-2573

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The tightly regulated copper window in yeast

S. V. Wegner, F. Sun, N. Hernandez and C. He, Chem. Commun., 2011, 47, 2571 DOI: 10.1039/C0CC04292G

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