Issue 4, 2011
From the journal:

Chemical Communications

PNAs grafted with (α/γ, R/S)-aminomethylene pendants: Regio and stereo specific effects on DNA binding and improved cell uptake†

Roopa Mitrab  and  K. N. Ganesh*ab  

* Corresponding authors

a Indian Institute of Science Education and Research, 900, NCL Innovation Park, Dr HomiBhabha Road, Pune 411008, India
E-mail: kn.ganesh@iiserpune.ac.in
Fax: 91 (20) 2589 9790
Tel: 91 (20) 2590 8006

b Division of Organic Chemistry, National Chemical Laboratory, Dr Homi Bhabha Road, Pune 411008, India

Abstract

PNAs grafted with cationic aminomethylene (am) pendants on the backbone at the glycyl (α) or ethylenediamine (γ) segments show regio (α/γ) and stereochemistry (R/S) dependent binding with complementary DNA. These are efficiently taken up by cells, with γ(S-am)aeg-PNA being the best in all properties.

Graphical abstract: PNAs grafted with (α/γ, R/S)-aminomethylene pendants: Regio and stereo specific effects on DNA binding and improved cell uptake

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Article information

DOI
https://doi.org/10.1039/C0CC03988H
Article type
Communication
Submitted
20 Sep 2010
Accepted
27 Oct 2010
First published
25 Nov 2010

Chem. Commun., 2011,47, 1198-1200

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PNAs grafted with (α/γ, R/S)-aminomethylene pendants: Regio and stereo specific effects on DNA binding and improved cell uptake

R. Mitra and K. N. Ganesh, Chem. Commun., 2011, 47, 1198 DOI: 10.1039/C0CC03988H

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