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Issue 3, 2011
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Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin

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Abstract

A robust protocol for the CuI-catalysed arylation of amidines is presented. Whilst the initially identified conditions were useful for benzamidine-derived substrates, difficulties were encountered with more complex substrates. This problem was overcome following a change in ligand type, enabling the synthesis of analogues of the chemical tool, blebbistatin.

Graphical abstract: Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin

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Publication details

The article was received on 02 Sep 2010, accepted on 26 Oct 2010 and first published on 15 Nov 2010


Article type: Communication
DOI: 10.1039/C0CC03624B
Chem. Commun., 2011,47, 1057-1059

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    Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin

    C. P. A. T. Lawson, A. M. Z. Slawin and N. J. Westwood, Chem. Commun., 2011, 47, 1057
    DOI: 10.1039/C0CC03624B

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