Issue 3, 2011
From the journal:

Chemical Communications

Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin†

Christopher P. A. T. Lawson,a   Alexandra M. Z. Slawina  and  Nicholas J. Westwood*a  

* Corresponding authors

a School of Chemistry and the Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife, UK
E-mail: njw3@st-andrews.ac.uk
Fax: +44 (0)1334 462595
Tel: +44 (0)1334 463816

Abstract

A robust protocol for the CuI-catalysed arylation of amidines is presented. Whilst the initially identified conditions were useful for benzamidine-derived substrates, difficulties were encountered with more complex substrates. This problem was overcome following a change in ligand type, enabling the synthesis of analogues of the chemical tool, blebbistatin.

Graphical abstract: Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin

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Article information

DOI
https://doi.org/10.1039/C0CC03624B
Article type
Communication
Submitted
02 Sep 2010
Accepted
26 Oct 2010
First published
15 Nov 2010

Chem. Commun., 2011,47, 1057-1059

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Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin

C. P. A. T. Lawson, A. M. Z. Slawin and N. J. Westwood, Chem. Commun., 2011, 47, 1057 DOI: 10.1039/C0CC03624B

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