Issue 1, 2011
From the journal:

Chemical Communications

Coarse-grained simulations of stretching entangled DNA using oscillating electric fields†‡

Richard S. Graham*a  and  Ronald G. Larsonb  

* Corresponding authors

a School of Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, UK
E-mail: Richard.Graham@nottingham.ac.uk

b Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA

Abstract

DNA stretching in entangling media with oscillating electric fields is useful in DNA sequencing. We propose that stretching occurs around hairpin loops at the chain ends, caused by interactions with the medium. Brownian dynamics simulations show that this mechanism explains several experimental observations, including a resonance with varying field frequency.

Graphical abstract: Coarse-grained simulations of stretching entangled DNA using oscillating electric fields

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Article information

DOI
https://doi.org/10.1039/C0CC02090G
Article type
Communication
Submitted
25 Jun 2010
Accepted
06 Aug 2010
First published
08 Sep 2010

Chem. Commun., 2011,47, 337-339

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Coarse-grained simulations of stretching entangled DNA using oscillating electric fields

R. S. Graham and R. G. Larson, Chem. Commun., 2011, 47, 337 DOI: 10.1039/C0CC02090G

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