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Issue 48, 2010
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Asymmetric total synthesis of (+)-fumimycin via 1,2-addition to ketimines

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Abstract

The first asymmetric total synthesis of fumimycin was accomplished. As a key step, a 1,2-addition of methyl Grignard reagents to ketimines with quinine as additive was employed. The absolute configuration of (+)-fumimycin was determined by CD-spectroscopy combined with time-dependent density functional calculations.

Graphical abstract: Asymmetric total synthesis of (+)-fumimycin via 1,2-addition to ketimines

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Publication details

The article was received on 22 Aug 2010, accepted on 05 Oct 2010 and first published on 28 Oct 2010


Article type: Communication
DOI: 10.1039/C0CC03399E
Citation: Chem. Commun., 2010,46, 9215-9217

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    Asymmetric total synthesis of (+)-fumimycin via 1,2-addition to ketimines

    P. J. Gross, F. Furche, M. Nieger and S. Bräse, Chem. Commun., 2010, 46, 9215
    DOI: 10.1039/C0CC03399E

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