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Issue 47, 2010
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Tetra-end-linked oligonucleotides forming DNAG-quadruplexes: a new class of aptamers showing anti-HIV activity

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Abstract

The biophysical and biological properties of unprecedented anti-HIV aptamers are presented. The most active aptamer (1L) shows a significant affinity to the HIV protein gp120.

Graphical abstract: Tetra-end-linked oligonucleotides forming DNA G-quadruplexes: a new class of aptamers showing anti-HIV activity

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Publication details

The article was received on 28 Jul 2010, accepted on 05 Oct 2010 and first published on 25 Oct 2010


Article type: Communication
DOI: 10.1039/C0CC02866E
Chem. Commun., 2010,46, 8971-8973

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    Tetra-end-linked oligonucleotides forming DNA G-quadruplexes: a new class of aptamers showing anti-HIV activity

    G. Oliviero, J. Amato, N. Borbone, S. D'Errico, A. Galeone, L. Mayol, S. Haider, O. Olubiyi, B. Hoorelbeke, J. Balzarini and G. Piccialli, Chem. Commun., 2010, 46, 8971
    DOI: 10.1039/C0CC02866E

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