Issue 41, 2010
From the journal:

Chemical Communications

Ligand dimerization programmed by hybridization to study multimeric ligand–receptor interactions†‡

Katarzyna Gorska,§a   Julien Beyrath,§b   Sylvie Fournel,b   Gilles Guichardb  and  Nicolas Winssinger*a  

* Corresponding authors

a Institut de Science et Ingenierie Supramoleculaires (ISIS), Université de Strasbourg—CNRS (UMR 7006), 8 allee Gaspard Monge, 67000 Strasbourg, France
E-mail: winssinger@isis.u-strasbg.fr
Fax: +33 3 90 24 51 12
Tel: +33 (0)3 68 85 51 13

b Centre National de la Recherche Scientifique UPR 9021, Immunologie et Chimie Thérapeutiques, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg, France

Abstract

Oligomerization of receptors induced or stabilized by polyvalent ligands is a fundamental mechanism in cellular recognition and signal transduction. Herein we report a general approach to encode complex peptide macrocycles with peptide nucleic acid (PNA) tags and program their oligomerization through hybridization as exemplified with a ligand binding to oligomeric DR5, a receptor of TRAIL cytokine.

Graphical abstract: Ligand dimerization programmed by hybridization to study multimeric ligand–receptor interactions

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Article information

DOI
https://doi.org/10.1039/C0CC02852E
Article type
Communication
Submitted
28 Jul 2010
Accepted
23 Aug 2010
First published
20 Sep 2010

Chem. Commun., 2010,46, 7742-7744

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Ligand dimerization programmed by hybridization to study multimeric ligand–receptor interactions

K. Gorska, J. Beyrath, S. Fournel, G. Guichard and N. Winssinger, Chem. Commun., 2010, 46, 7742 DOI: 10.1039/C0CC02852E

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