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Issue 39, 2010
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Metal-catalyzed asymmetric conjugate addition reaction: formation of quaternary stereocenters

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Abstract

All-carbon quaternary stereocenters are ubiquitous motifs in biological products and pharmaceutical agents. However, due to sterical reasons, these centers are not always easily accessible. The metal-catalyzed conjugate addition reaction to trisubstituted conjugated substrates presents a viable methodology to create quaternary centers. In this article, different ways of activating the conjugate system towards nucleophilic addition will be described. An overview will be given on the different types of quaternary centers that are accessible through the conjugate addition reaction.

Graphical abstract: Metal-catalyzed asymmetric conjugate addition reaction: formation of quaternary stereocenters

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Article information


Submitted
01 Jul 2010
Accepted
04 Aug 2010
First published
24 Aug 2010

Chem. Commun., 2010,46, 7295-7306
Article type
Feature Article

Metal-catalyzed asymmetric conjugate addition reaction: formation of quaternary stereocenters

C. Hawner and A. Alexakis, Chem. Commun., 2010, 46, 7295
DOI: 10.1039/C0CC02309D

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