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Issue 36, 2010
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α-Synuclein in α-helical conformation at air–water interface: implication of conformation and orientation changes during its accumulation/aggregation

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Abstract

α-Synuclein, a natively unstructured protein important in the neuropathology of Parkinson's disease, was found to form a Langmuir monolayer in an α-helical conformation with its helical axis parallel to the air–water interface. This study sheds light on the role of vesicles in neuronal cells in the accumulation/aggregation of α-synuclein.

Graphical abstract: α-Synuclein in α-helical conformation at air–water interface: implication of conformation and orientation changes during its accumulation/aggregation

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Article information


Submitted
25 Jun 2010
Accepted
26 Jul 2010
First published
16 Aug 2010

Chem. Commun., 2010,46, 6702-6704
Article type
Communication

α-Synuclein in α-helical conformation at air–water interface: implication of conformation and orientation changes during its accumulation/aggregation

C. Wang, N. Shah, G. Thakur, F. Zhou and R. M. Leblanc, Chem. Commun., 2010, 46, 6702
DOI: 10.1039/C0CC02098B

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