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Issue 43, 2010
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Sandwich probes: two simultaneous reactions for templated nucleic acid detection

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Abstract

Fluorescence-quenched nucleic acid probes with reactive moieties at both the 5′ and 3′ ends are synthesized and tested for reaction with two adjacent nucleophile-containing DNAs. These probes improve signal to background over singly reactive probes and can discriminate single nucleotide polymorphisms in the target DNA or RNA.

Graphical abstract: Sandwich probes: two simultaneous reactions for templated nucleic acid detection

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Supplementary files

Article information


Submitted
19 Jun 2010
Accepted
14 Sep 2010
First published
07 Oct 2010

Chem. Commun., 2010,46, 8154-8156
Article type
Communication

Sandwich probes: two simultaneous reactions for templated nucleic acid detection

D. J. Kleinbaum and E. T. Kool, Chem. Commun., 2010, 46, 8154
DOI: 10.1039/C0CC01968B

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