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Issue 35, 2010
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A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives

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Abstract

ESI mass spectrometry was used to assess the binding of 13-substituted, 5-nitro-2-phenylindolyl- and 2-naphthalenyl-based berberine derivatives to inter- and intramolecular G-quadruplex DNA molecules. In contrast with the parent berberine, the compounds showed selectivity for quadruplex over duplex DNA and stabilised the quadruplex structure. They represent a new class of quadruplex DNA-selective ligands.

Graphical abstract: A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives

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Publication details

The article was received on 17 Jun 2010, accepted on 16 Jul 2010 and first published on 16 Aug 2010


Article type: Communication
DOI: 10.1039/C0CC01933J
Chem. Commun., 2010,46, 6602-6604

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    A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives

    K. C. Gornall, S. Samosorn, B. Tanwirat, A. Suksamrarn, J. B. Bremner, M. J. Kelso and J. L. Beck, Chem. Commun., 2010, 46, 6602
    DOI: 10.1039/C0CC01933J

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