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Issue 41, 2010
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Efficient and chemoselective alkylation of amines/amino acids using alcohols as alkylating reagents under mild conditions

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Abstract

We report a mild and environmentally benign method for the synthesis of tertiary amines using alcohols as the alkylating reagents. Not only secondary amines such as piperazines but also amino acids and amino alcohols can be N-alkylated selectively. For N,O-benzyl protected amino alcohols, both N,O-de-benzylation and N-methylation were achieved in one-pot.

Graphical abstract: Efficient and chemoselective alkylation of amines/amino acids using alcohols as alkylating reagents under mild conditions

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Publication details

The article was received on 19 May 2010, accepted on 19 Jul 2010 and first published on 09 Sep 2010


Article type: Communication
DOI: 10.1039/C0CC01487G
Chem. Commun., 2010,46, 7834-7836

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    Efficient and chemoselective alkylation of amines/amino acids using alcohols as alkylating reagents under mild conditions

    C. Xu, Z. Xiao, B. Zhuo, Y. Wang and P. Huang, Chem. Commun., 2010, 46, 7834
    DOI: 10.1039/C0CC01487G

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