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Issue 44, 2010
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Ligand development in the Ni-catalyzed hydrocyanation of alkenes

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The addition of HCN to alkenes is a very useful reaction for the synthesis of functional organic substrates. Industrially the nickel-catalyzed hydrocyanation has gained considerable importance mainly because of the production of adiponitrile in the DuPont process. In this process the hydrocyanation of butadiene is carried out using aryl phosphite-modified nickel catalyst. Since the performance of organo-transition metal complexes is largely determined by the ligand environment of the metal, fundamental understanding and ligand development is of pivotal importance for any progress. This feature article gives an account of the development and application of different mono- and bidentate phosphorus-based ligands in the Ni-catalyzed hydrocyanation reaction of alkenes. Special attention will be paid to the development of insight and understanding of the ligand structural and electronic properties towards the improvement of the catalyst performance in terms of stability, activity, and selectivity.

Graphical abstract: Ligand development in the Ni-catalyzed hydrocyanation of alkenes

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The article was received on 17 May 2010, accepted on 17 Sep 2010 and first published on 25 Oct 2010

Article type: Feature Article
DOI: 10.1039/C0CC01452D
Chem. Commun., 2010,46, 8325-8334

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    Ligand development in the Ni-catalyzed hydrocyanation of alkenes

    L. Bini, C. Müller and D. Vogt, Chem. Commun., 2010, 46, 8325
    DOI: 10.1039/C0CC01452D

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