Issue 37, 2010
From the journal:

Chemical Communications

Thioether binding mediates monofunctional platinum antitumor reagents to trans configuration in DNA interactions†

Guolin Ma,a   Yuanzeng Min,a   Fan Huang,a   Tao Jianga  and  Yangzhong Liu*a  

* Corresponding authors

a Department of Chemistry, CAS Key Laboratory of Soft Matter Chemistry, University of Science and Technology of China, Hefei, Anhui, China
E-mail: liuyz@ustc.edu.cn
Fax: (+86) 551-3600874
Tel: (+86) 551-3600874

Abstract

Methionine binding converts monofunctional platinum antitumor agents to trans configuration adducts in the reaction with DNA, which suggests the correlation of two classes of platinum complexes in the antitumor mechanism.

Graphical abstract: Thioether binding mediates monofunctional platinum antitumor reagents to trans configuration in DNA interactions

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Article information

DOI
https://doi.org/10.1039/C0CC01408G
Article type
Communication
Submitted
14 May 2010
Accepted
26 Jul 2010
First published
23 Aug 2010

Chem. Commun., 2010,46, 6938-6940

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Thioether binding mediates monofunctional platinum antitumor reagents to trans configuration in DNA interactions

G. Ma, Y. Min, F. Huang, T. Jiang and Y. Liu, Chem. Commun., 2010, 46, 6938 DOI: 10.1039/C0CC01408G

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