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Issue 30, 2010
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Clickable peptide nucleic acids (cPNA) with tunable affinity

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Abstract

Peptide nucleic acids (PNAs) are functional analogues of natural oligonucleotides. Herein, we report the synthesis of PNAs bearing a triazole in lieu of the amide bond assembled using a “click” cycloaddition, their hybridization properties as well as the DNA-templated coupling of the azide and alkyne PNA fragments.

Graphical abstract: Clickable peptide nucleic acids (cPNA) with tunable affinity

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Article information


Submitted
22 Apr 2010
Accepted
09 Jun 2010
First published
23 Jun 2010

Chem. Commun., 2010,46, 5476-5478
Article type
Communication

Clickable peptide nucleic acids (cPNA) with tunable affinity

D. Chouikhi, S. Barluenga and N. Winssinger, Chem. Commun., 2010, 46, 5476
DOI: 10.1039/C0CC01081B

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