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Issue 41, 2010
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Gold(i) complex of N,N′-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties—potent tight-binding inhibition of thioredoxin reductase

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Abstract

Coinage metal complexes of an N,N-disubstituted cyclic thiourea exert significant cytotoxicities to cancer cells and, in particular, the gold(I) thiourea complex exhibits a potent tight-binding inhibition of the anticancer drug target thioredoxin reductase with an inhibitory constant at nanomolar level.

Graphical abstract: Gold(i) complex of N,N′-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties—potent tight-binding inhibition of thioredoxin reductase

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Publication details

The article was received on 21 Apr 2010, accepted on 14 Jun 2010 and first published on 09 Jul 2010


Article type: Communication
DOI: 10.1039/C0CC01058H
Chem. Commun., 2010,46, 7691-7693

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    Gold(I) complex of N,N-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties—potent tight-binding inhibition of thioredoxin reductase

    K. Yan, C. Lok, K. Bierla and C. Che, Chem. Commun., 2010, 46, 7691
    DOI: 10.1039/C0CC01058H

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