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Issue 31, 2010
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Chemoenzymatic synthesis of glycosylphosphatidylinositol-anchored glycopeptides

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Abstract

MUC1 glycopeptide was efficiently coupled to glycosylphosphatidylinositol (GPI) derivatives by sortase A (SrtA), verifying that SrtA can accept sterically hindered glycopeptide as substrate for ligation with GPIs. This work has established a practical method for the chemoenzymatic synthesis of GPI-linked glycopeptides.

Graphical abstract: Chemoenzymatic synthesis of glycosylphosphatidylinositol-anchored glycopeptides

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Publication details

The article was received on 08 Apr 2010, accepted on 26 May 2010 and first published on 24 Jun 2010


Article type: Communication
DOI: 10.1039/C0CC00828A
Chem. Commun., 2010,46, 5773-5774

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    Chemoenzymatic synthesis of glycosylphosphatidylinositol-anchored glycopeptides

    Z. Wu, X. Guo and Z. Guo, Chem. Commun., 2010, 46, 5773
    DOI: 10.1039/C0CC00828A

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