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Issue 30, 2010
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Construction of a quaternary carbon at the carbonylcarbon of the cyclohexane ring

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Abstract

High SN2′ selectivity in the allylic substitution of cyclohexylidene ethyl picolinates with copper reagents prepared from RMgBr and CuBr·Me2S was realized by addition of ZnX2 (X = I, Br, Cl). Furthermore, ZnX2 accelerated the reaction with the bulky iPr reagent.

Graphical abstract: Construction of a quaternary carbon at the carbonyl carbon of the cyclohexane ring

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Article information


Submitted
29 Mar 2010
Accepted
09 Jun 2010
First published
29 Jun 2010

Chem. Commun., 2010,46, 5482-5484
Article type
Communication

Construction of a quaternary carbon at the carbonyl carbon of the cyclohexane ring

Y. Kaneko, Y. Kiyotsuka, H. P. Acharya and Y. Kobayashi, Chem. Commun., 2010, 46, 5482
DOI: 10.1039/C0CC00653J

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