Issue 23, 2010
From the journal:

Chemical Communications

Assembly of dsDNA nanocircles into dimeric and oligomeric aggregates†

Damian Ackermann,‡a   Goran Rasched,‡a   Sandeep Verma,b   Thorsten L. Schmidt,c   Alexander Heckelc  and  Michael Famulok*a  

* Corresponding authors

a LIMES Institute, Chemical Biology & Medicinal Chemistry Unit, University of Bonn, 53121 Bonn, Germany
E-mail: m.famulok@uni-bonn.de
Fax: +49 228-735388

b Department of Chemistry, Indian Institute of Technology, Kanpur 208016 (UP), India
E-mail: sverma@iitk.ac.in
Fax: +91 512-597436

c Cluster of Excellence Macromolecular Complexes, University Frankfurt, 60438 Frankfurt, Germany
E-mail: heckel@em.uni-frankfurt.de
Fax: +49 69-798-29823

Abstract

The assembly of double-stranded (ds) DNA nanocircles both by hybridization with branched oligodeoxynucleotides (ODNs) and by intercalation was analyzed by atomic force microscopy (AFM). Branched ODNs ligated to single-stranded (ss) gap regions of dsDNA nanocircles led to defined, dumbbell-shaped architectures. ODNs containing an aromatic intercalator yielded oligomeric aggregates.

Graphical abstract: Assembly of dsDNA nanocircles into dimeric and oligomeric aggregates

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Article information

DOI
https://doi.org/10.1039/C0CC00390E
Article type
Communication
Submitted
15 Mar 2010
Accepted
29 Apr 2010
First published
17 May 2010

Chem. Commun., 2010,46, 4154-4156

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Assembly of dsDNA nanocircles into dimeric and oligomeric aggregates

D. Ackermann, G. Rasched, S. Verma, T. L. Schmidt, A. Heckel and M. Famulok, Chem. Commun., 2010, 46, 4154 DOI: 10.1039/C0CC00390E

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