Issue 29, 2010
From the journal:

Chemical Communications

Synthesis, RNA selective hybridization and high nuclease resistance of an oligonucleotide containing novel bridged nucleic acid with cyclic urea structure†

Masaru Nishida,a   Takeshi Baba,a   Tetsuya Kodama,a   Aiko Yahara,a   Takeshi Imanishia  and  Satoshi Obika*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, Japan
E-mail: obika@phs.osaka-u.ac.jp
Fax: +81 6 6879 8204
Tel: +81 6 6879 8200

Abstract

A novel bridged nucleic acid bearing cyclic urea structure was successfully synthesized and introduced into oligonucleotide, displaying attractive characteristics of highly RNA selective hybridization ability and excellent resistance towards nuclease degradation.

Graphical abstract: Synthesis, RNA selective hybridization and high nuclease resistance of an oligonucleotide containing novel bridged nucleic acid with cyclic urea structure

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C0CC00154F
Article type
Communication
Submitted
27 Feb 2010
Accepted
26 May 2010
First published
22 Jun 2010

Chem. Commun., 2010,46, 5283-5285

Permissions

Request permissions

Synthesis, RNA selective hybridization and high nuclease resistance of an oligonucleotide containing novel bridged nucleic acid with cyclic urea structure

M. Nishida, T. Baba, T. Kodama, A. Yahara, T. Imanishi and S. Obika, Chem. Commun., 2010, 46, 5283 DOI: 10.1039/C0CC00154F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements