Issue 23, 2010
From the journal:

Chemical Communications

Ruthenium/TFA-catalyzed regioselective C-3-alkylation of indoles with terminal alkynes in water: efficient and unprecedented access to 3-(1-methylalkyl)-1H-indoles†

Victorio Cadierno,*a   Javier Francosa  and  José Gimeno*a  

* Corresponding authors

a Departamento de Química Orgánica e Inorgánica. IUQOEM, University of Oviedo, E-33006 Oviedo, Spain
E-mail: vcm@uniovi.es, jgh@uniovi.es
Fax: (+34)985103446
Tel: (+34)985102985

Abstract

An unprecedented C-3-alkylation reaction of indoles with terminal alkynes in aqueous medium has been developed using catalytic amounts of ruthenium and trifluoroacetic acid.

Graphical abstract: Ruthenium/TFA-catalyzed regioselective C-3-alkylation of indoles with terminal alkynes in water: efficient and unprecedented access to 3-(1-methylalkyl)-1H-indoles

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Article information

DOI
https://doi.org/10.1039/C002804E
Article type
Communication
Submitted
09 Feb 2010
Accepted
09 Apr 2010
First published
28 Apr 2010

Chem. Commun., 2010,46, 4175-4177

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Ruthenium/TFA-catalyzed regioselective C-3-alkylation of indoles with terminal alkynes in water: efficient and unprecedented access to 3-(1-methylalkyl)-1H-indoles

V. Cadierno, J. Francos and J. Gimeno, Chem. Commun., 2010, 46, 4175 DOI: 10.1039/C002804E

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