Jump to main content
Jump to site search

Issue 19, 2010
Previous Article Next Article

Silver-catalyzed intramolecular cyclization of 9-propargyladeninevia N3 alkylation

Author affiliations

Abstract

We report the formation of a highly unusual fused, tricyclic purine derivative via N3 alkylation of 9-propargyladenine, upon activation of the acetylenic triple bond by Ag(I) ions. The participation of silver ions in this process might offer newer design paradigms for minor groove N3 DNA alkylation, antibacterial and anticancer agents.

Graphical abstract: Silver-catalyzed intramolecular cyclization of 9-propargyladenine via N3 alkylation

Back to tab navigation

Supplementary files

Publication details

The article was received on 28 Jan 2010, accepted on 05 Mar 2010 and first published on 06 Apr 2010


Article type: Communication
DOI: 10.1039/C001947J
Chem. Commun., 2010,46, 3312-3314

  •   Request permissions

    Silver-catalyzed intramolecular cyclization of 9-propargyladenine via N3 alkylation

    R. K. Prajapati, J. Kumar and S. Verma, Chem. Commun., 2010, 46, 3312
    DOI: 10.1039/C001947J

Search articles by author

Spotlight

Advertisements