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Issue 16, 2010
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One-pot synthesis of substituted isoindolin-1-ones via lithiation and substitution of N′-benzyl-N,N-dimethylureas

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Abstract

Lithiation of various N′-benzyl-N,N-dimethylureas with t-BuLi (3.3 mole equivalents) in anhydrous THF at 0 °C followed by reactions with various electrophiles afforded the corresponding 3-substituted isoindolin-1-ones in high yields.

Graphical abstract: One-pot synthesis of substituted isoindolin-1-ones via lithiation and substitution of N′-benzyl-N,N-dimethylureas

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Article information


Submitted
22 Dec 2009
Accepted
13 Feb 2010
First published
25 Feb 2010

Chem. Commun., 2010,46, 2790-2792
Article type
Communication

One-pot synthesis of substituted isoindolin-1-ones via lithiation and substitution of N′-benzyl-N,N-dimethylureas

K. Smith, G. A. El-Hiti and A. S. Hegazy, Chem. Commun., 2010, 46, 2790
DOI: 10.1039/B926983E

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