Issue 19, 2010
From the journal:

Chemical Communications

Label-free and naked eye detection ofPNA/DNA hybridization using enhancement of gold nanoparticles†

Sang Kyu Kim,ab   Hyunmin Cho,ab   Jinyoung Jeong,ab   Ji Na Kwon,ab   Yongwon Jungab  and  Bong Hyun Chung*ab  

* Corresponding authors

a BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yuseong, Daejeon 305-600, Republic of Korea
E-mail: chungbh@kribb.re.kr
Fax: +82-42-879-8594
Tel: +82-42-860-4442

b School of Engineering, University of Science and Technology (UST), P.O. Box 115, Yuseong, Daejeon 305-600, Republic of Korea

Abstract

Utilizing a gold enhancement process after inducing electrostatic interaction between positively charged gold nanoparticles and negatively charged target DNA hybridized to neutral PNA capture probes, a new method for label-free detection of DNA was developed and successfully applied to detect H5-type DNA.

Graphical abstract: Label-free and naked eye detection of PNA/DNA hybridization using enhancement of gold nanoparticles

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Article information

DOI
https://doi.org/10.1039/B926940A
Article type
Communication
Submitted
22 Dec 2009
Accepted
05 Mar 2010
First published
01 Apr 2010

Chem. Commun., 2010,46, 3315-3317

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Label-free and naked eye detection of PNA/DNA hybridization using enhancement of gold nanoparticles

S. K. Kim, H. Cho, J. Jeong, J. N. Kwon, Y. Jung and B. H. Chung, Chem. Commun., 2010, 46, 3315 DOI: 10.1039/B926940A

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