Issue 8, 2010
From the journal:

Chemical Communications

Highly diastereoselective synthesis of modified nucleosides via an asymmetric multicomponent reaction†

Arun K. Ghosh*a  and  Jorden Kassa  

* Corresponding authors

a Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, USA
E-mail: akghosh@purdue.edu
Fax: +1 765-496-1612
Tel: +1 765-494-5323

Abstract

We have developed a practical synthesis of unique nucleoside derivatives via TiCl4 promoted multicomponent reaction of optically active dihydrofuran, ethyl pyruvate/glyoxylate, and a TMS protected nucleobase in a single-pot operation.

Graphical abstract: Highly diastereoselective synthesis of modified nucleosides via an asymmetric multicomponent reaction

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Article information

DOI
https://doi.org/10.1039/B924807B
Article type
Communication
Submitted
25 Nov 2009
Accepted
11 Jan 2010
First published
25 Jan 2010

Chem. Commun., 2010,46, 1218-1220

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Highly diastereoselective synthesis of modified nucleosides via an asymmetric multicomponent reaction

A. K. Ghosh and J. Kass, Chem. Commun., 2010, 46, 1218 DOI: 10.1039/B924807B

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