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Issue 9, 2010
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Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles

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Abstract

The utility of wild-type and variant carboxymethylproline synthases for biocatalysis was demonstrated by preparing functionalised 5-, 6- and 7-membered N-heterocycles from amino acid aldehydes and (alkylated) malonyl-coenzyme A derivatives; the N-heterocycles produced were converted to the corresponding bicyclic β-lactams by a carbapenem synthetase.

Graphical abstract: Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles

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Article information


Submitted
23 Nov 2009
Accepted
22 Dec 2009
First published
12 Jan 2010

Chem. Commun., 2010,46, 1413-1415
Article type
Communication

Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles

R. B. Hamed, J. Mecinović, C. Ducho, T. D. W. Claridge and C. J. Schofield, Chem. Commun., 2010, 46, 1413
DOI: 10.1039/B924519G

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