Issue 13, 2010

In situazide formation and “click” reaction of nile red with DNA as an alternative postsynthetic route

Abstract

Oligonucleotides that contain a 5-iodo-2′-deoxyuridine in the sequence can be applied for a postsynthetic “click”-type modification with ethynyl-modified nile red as a fluorescent label by in situ formation of the intermediate azide.

Graphical abstract: In situ azide formation and “click” reaction of nile red with DNA as an alternative postsynthetic route

Supplementary files

Article information

Article type
Communication
Submitted
23 Nov 2009
Accepted
22 Dec 2009
First published
18 Jan 2010

Chem. Commun., 2010,46, 2230-2231

In situ azide formation and “click” reaction of nile red with DNA as an alternative postsynthetic route

C. Beyer and H. Wagenknecht, Chem. Commun., 2010, 46, 2230 DOI: 10.1039/B924471A

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