Issue 12, 2010
From the journal:

Chemical Communications

Design and efficient synthesis of a new scaffold based on unsymmetrical protoporphyrin IX derivatives for use in SPPS†

M.-E. Bakleh,a   V. Sol,*ab   R. Granet,a   G. Déléris,c   K. Estieu-Gionnetc  and  P. Krausza  

* Corresponding authors

a Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069 Faculté des Sciences et Techniques, 123 Avenue Albert Thomas, 87060 Limoges, France
E-mail: vincent.sol@unilim.fr

b Department of Chemistry, University of Hull, Cottingham Road, Hull, UK
E-mail: V.Sol@hull.ac.uk

c Université Bordeaux 2, CNRS UMR5084, Groupe de Chimie Bio-Organique, 146 rue Léo Saignat, 33076 Bordeaux, France

Abstract

Fmoc-protected amine derivatives of Protoporphyrin IX were synthesized by two original methods using solid-phase chemistry. The new compounds represent unsymmetrical scaffolds suitable for the generation of a large range of peptidic porphyrin derivatives through SPPS strategy.

Graphical abstract: Design and efficient synthesis of a new scaffold based on unsymmetrical protoporphyrin IX derivatives for use in SPPS

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Article information

DOI
https://doi.org/10.1039/B922012G
Article type
Communication
Submitted
21 Oct 2009
Accepted
27 Jan 2010
First published
12 Feb 2010

Chem. Commun., 2010,46, 2115-2117

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Design and efficient synthesis of a new scaffold based on unsymmetrical protoporphyrin IX derivatives for use in SPPS

M.-E. Bakleh, V. Sol, R. Granet, G. Déléris, K. Estieu-Gionnet and P. Krausz, Chem. Commun., 2010, 46, 2115 DOI: 10.1039/B922012G

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