Issue 46, 2009
From the journal:

Chemical Communications

Deazaflavins as mediators in light-driven cytochrome P450 catalyzed hydroxylations†

Felipe E. Zilly,‡a   Andreas Taglieber,‡a   Frank Schulz,a   Frank Hollmannb  and  Manfred T. Reetz*a  

* Corresponding authors

a Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, Mülheim an der Ruhr, Germany
E-mail: reetz@mpi-muelheim.mpg
Fax: +49-208-306-2985
Tel: +49-208-306-2000

b Delft University of Technology, Julianalaan 136, Delft, the Netherlands
E-mail: F.Hollmann@tudelft.nl
Fax: +31-15-278-1415
Tel: +31-15-278-195

Abstract

A light-driven deazaflavin-dependent direct enzyme regeneration system has been developed for a P450-BM3 catalyzed CH-activating hydroxylation, thereby avoiding the need for the expensive NADPH cofactor.

Graphical abstract: Deazaflavins as mediators in light-driven cytochrome P450 catalyzed hydroxylations

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Article information

DOI
https://doi.org/10.1039/B913863C
Article type
Communication
Submitted
10 Jul 2009
Accepted
21 Sep 2009
First published
14 Oct 2009

Chem. Commun., 2009, 7152-7154

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Deazaflavins as mediators in light-driven cytochrome P450 catalyzed hydroxylations

F. E. Zilly, A. Taglieber, F. Schulz, F. Hollmann and M. T. Reetz, Chem. Commun., 2009, 7152 DOI: 10.1039/B913863C

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