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Issue 46, 2009
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Deazaflavins as mediators in light-driven cytochrome P450 catalyzed hydroxylations

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Abstract

A light-driven deazaflavin-dependent direct enzyme regeneration system has been developed for a P450-BM3 catalyzed CH-activating hydroxylation, thereby avoiding the need for the expensive NADPH cofactor.

Graphical abstract: Deazaflavins as mediators in light-driven cytochrome P450 catalyzed hydroxylations

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Article information


Submitted
10 Jul 2009
Accepted
21 Sep 2009
First published
14 Oct 2009

Chem. Commun., 2009, 7152-7154
Article type
Communication

Deazaflavins as mediators in light-driven cytochrome P450 catalyzed hydroxylations

F. E. Zilly, A. Taglieber, F. Schulz, F. Hollmann and M. T. Reetz, Chem. Commun., 2009, 7152
DOI: 10.1039/B913863C

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