Issue 37, 2009
From the journal:

Chemical Communications

High temperature zincation of functionalized aromatics and heteroaromatics using TMPZnCl·LiCl and microwave irradiation†

Marc Mosrin,a   Gabriel Monzon,a   Tomke Bressera  and  Paul Knochel*a  

* Corresponding authors

a Department Chemie, Ludwig-Maximilians-Universität München, Butenandstraße 5-13, Haus F, Germany
E-mail: Paul.Knochel@cup.uni-muenchen.de.
Fax: +49 89-2180-77680
Tel: +49 2180-77681

Abstract

A wide range of functional aryl and heteroaryl zinc reagents have been efficiently prepared via regio- and chemoselective zincation using TMPZnCl·LiCl and irradiation. Sensitive functional groups like esters are compatible with the high temperatures of the reactions. The resulting zinc species undergo a number of subsequent reactions, providing highly functionalized aromatics and heteroaromatics in high yields.

Graphical abstract: High temperature zincation of functionalized aromatics and heteroaromatics using TMPZnCl·LiCl and microwave irradiation

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B913693B
Article type
Communication
Submitted
09 Jul 2009
Accepted
12 Aug 2009
First published
24 Aug 2009

Chem. Commun., 2009, 5615-5617

Permissions

Request permissions

High temperature zincation of functionalized aromatics and heteroaromatics using TMPZnCl·LiCl and microwave irradiation

M. Mosrin, G. Monzon, T. Bresser and P. Knochel, Chem. Commun., 2009, 5615 DOI: 10.1039/B913693B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements