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Issue 38, 2009
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Palladium-catalysed arylative cyclisation of N-allylacetamides with aryl halides yielding benzyl-substituted oxazolines

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Abstract

Treatment of N-allylacetamide with aryl halide in the presence of sodium t-butoxide and a palladium catalyst leads to arylative cyclisation to provide the corresponding benzyl-substituted oxazoline in high yield.

Graphical abstract: Palladium-catalysed arylative cyclisation of N-allylacetamides with aryl halides yielding benzyl-substituted oxazolines

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Supplementary files

Article information


Submitted
30 Jun 2009
Accepted
21 Aug 2009
First published
03 Sep 2009

Chem. Commun., 2009, 5754-5756
Article type
Communication

Palladium-catalysed arylative cyclisation of N-allylacetamides with aryl halides yielding benzyl-substituted oxazolines

D. Fujino, S. Hayashi, H. Yorimitsu and K. Oshima, Chem. Commun., 2009, 5754
DOI: 10.1039/B912895F

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