Issue 36, 2009

Copper-catalyzed enantioselectivecarbenoidinsertion into S–H bonds

Abstract

An asymmetriccarbenoidinsertion into S–H bonds catalyzed by copper–chiral spiro bisoxazoline complexes has been developed, in which a series of α-mercaptoesters were produced in high yields with moderate to good enantioselectivities (up to 85% ee); this result represents the best enantioselectivity in the catalytic asymmetriccarbenoid S–H bond insertion reaction.

Graphical abstract: Copper-catalyzed enantioselectivecarbenoidinsertion into S–H bonds

Supplementary files

Article information

Article type
Communication
Submitted
16 Jun 2009
Accepted
22 Jul 2009
First published
11 Aug 2009

Chem. Commun., 2009, 5362-5364

Copper-catalyzed enantioselectivecarbenoidinsertion into S–H bonds

Y. Zhang, S. Zhu, Y. Cai, H. Mao and Q. Zhou, Chem. Commun., 2009, 5362 DOI: 10.1039/B911670B

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